朱红艳-yb体育官方
师资介绍
姓名：朱红艳
性别：女
民族：汉族
出生年月：1978.06.23
职称：教授
学历：博士
职务：药物制剂系党支部书记
研究方向：1.核酸药物递释系统；2.仿生药物递送系统。
主持或参加科研项目（课题）
1. 江苏省自然科学基金面上项目，bk20201443，靶向调控肿瘤转移前微环境的工程化“外泌体影”仿生递释系统研究，2020/7-2023/6，10万元，在研，主持 ；
2. 国家自然科学基金青年基金项目，81202467，胞内触发释药的仿生型sirna自组装胶束纳米复合物的构建、抗肿瘤转移作用及细胞内药物动力学研究，2013/1-2015/12，23万元，已结题，主持 ；
3. 江苏省青年科学基金项目，bk2012232，靶向肿瘤血管生成的仿生型小核酸药物递释系统研究，，20万元，已结题，主持 ；
4. 江苏省教育厅高校自然科学研究面上项目，11kjb350004，谷胱甘肽触发释放的智能型sirna复合载体（穿膜肽tat-壳聚糖-量子点）的构建及其抗肿瘤活性研究，，3万元，已结题，主持 ；
5. 江苏省高校自然科学研究指导性项目，06kjd310150，南瓜多糖对链脲菌素诱导的胰岛损伤的保护作用及机制研究，2007/01-2008/12，1万元，已结题，主持。
6. 南通市课题，exosome@cbsa 仿生 sirna 递送系统的构建及其抗乳腺癌术后转移作用研究，2018.07-2020.06，项目编号：jc2018024，5万元。
代表性研究成果和学术奖励情况
第一作者和通讯作者论文，专利
(2) haiqin huang, lanlan shao, yan chen, weili han, yao zhou, tianqing liu, jinhua gu,* and hongyan zhu*. sequential dual delivery system based on sicox-2-loaded gold nanostar and thermal-sensitive liposomes overcome hypoxia mediated multidrug resistance in tumors. mol. pharmaceutics. 2022, 19(7):2390-2405.
(3) yongmei zhao, yuanlin zheng, yan zhu, hongyun li, hongyan zhu* and tianqing liu*. docetaxel-loaded m1 macrophage-derived exosomes for a safe and efficient chemoimmunotherapy of breast cancer. journal of nanobiotechnology. 2022, 20:359.
(4) haiqin huang, lanlan shao, yan chen, lan tang, tianqing liu, junxu li, and hongyan zhu*. synergistic strategy with hyperthermia therapy based immunotherapy and engineered exosomes liposomes targeted chemotherapy prevents tumor recurrence and metastasis in advanced breast cancer. bioeng transl med. 2021, 7(2):e10284.
(5) shengyu zhang, ye gan, lanlan shao, tianqing liu, danyi wei, yanyan yu,* hongwei guo,* and hongyan zhu*. virus mimetic shell-sheddable chitosan micelles for sivegf delivery and fret-traceable acid-triggered release. acs appl. mater. interfaces. 2020, 12, 53598−53614.（if=9.229）
(6) liuwan zhao, chunyan gu, ye gan, lanlan shao, hongwei chen, hongyan zhu*. exosome-mediated sirna delivery to suppress postoperative breast cancer metastasis. j control release. 2020, 318, 1-15.（if=9.776）
(7) ,, , , , , * and *. combined modality therapy based on hybrid gold nanostars coated with temperature sensitive liposomes to overcome paclitaxel-resistance in hepatic carcinoma. pharmaceutics 2019, 11(12), 683（if=6.321）
(8) yanyan yu, min zhou, wei zhang, lei huang, dandan miao, hongyan zhu*, gaoxing su*. rattle-type gold nanorods/porous-sio2 nanocomposites as near-infrared light-activated drug delivery systems for cancer combined chemo-photothermal therapy. mol. pharmaceutics. 2019,16(5) 1929-1938（if=4.939）
(9) , , , , , , , *. mesoporous silica-coated gold nanostars with drug payload for combined chemo-photothermal cancer therapy. 2019 feb; 27(2):201-210. （if=5.121）
(10) shengyu , yanjun , ye , nanqing , yueqing , hongyan zhu*. conjugates of tat and folate with dox-loaded chitosan micelles offer effective intracellular delivery ability. 2019, 24(2):253-261.（if=3.133）
(11) shengyu zhang, liuwan zhao, nanqin qiu, yanjun liu, bohui xu, hongyan zhu*, on the hypoxic tumor targeting ability of two chitosan micelles loaded with oil-soluble cdse quantum dots. 2018, 23(1):87-95.（if=3.133）
(12) hongyan zhu*, wanwan liu, ziting cheng, ke yao, yu yang, bohui xu and gaoxing su*, targeted delivery of sirna with ph-responsive hybrid gold nanostars for cancer treatment. 2017, 18(10):2029.（if=5.923）
(13) fei liu, yuan sun, chen kang, hongyan zhu*. pegylated drug delivery systems: from design to biomedical applications. nano life. 2016, 6(3, 4):1642002 (1-11).
(14) bohui xu, yubin wang, hongyan zhu*. mini-tablet combination for sustained release of clonidine hydrochloride and hydrochlorothiazide: preparation and pharmacokinetics in beagle dogs. pharmazie. 2016 71(2):76-83. （if=1.267）
(15) hongyan zhu, shengyu zhang, yongling, guoliang meng, yu yang, wei zhang*. j control release. 2015, 220(pt a):529-544. （if=9.776）
(16) hongyan zhu, guangtong chen, guoliang meng jiliang xu*. characterization of pumpkin polysaccharides and protective effects on streptozotocin-damaged islet cells. chin j nat med. 2015, 13(3):199-207. （if=3.000）
(17) hongyan zhu, jingping zhu, aimei xie, yong lin, beibei zhang, yifei wang, wei zhang*.visible quantum-dot-based targeted sirna delivery for hif-1α gene silencing. j. drug del. sci. tech. 2014, 24 (5): 445-451.（if=3.981）
(18) hongyan zhu, jie cao, sisi cui, zhiyu qian, yueqing gu*. enhanced tumor targeting and antitumor efficacy via hydroxycamptothecin-encapsulated folate-modified n-succinyl-n′-octyl chitosan micelles. j pharm sci. 2013, 102 (4):1318-1332. （if=3.534）
(19) hongyan zhu, fei liu, jing guo, jianpeng xue, zhiyu qian, yueqing gu*. folate-modified chitosan micelles with enhanced tumor targeting evaluated by near infrared imaging system. carbohydrate polymers. 2011, 86(3):1118-1129. （if=9.381）
(20) jie cao#, hongyan zhu#, dawei deng, bing xue, liping tang, didel mahounga, zhiyu qian, yueqing gu*, in vivo nir imaging with pbs quantum dots entrapped in biodegradable micelles. journal of biomedical materials research part a. 2012: 100a: 958-968. （if=4.396）
(21) 程紫婷，姚珂，刘婉婉，许伯慧，朱红艳*, 紫杉醇温敏脂质体与sirna金纳米星载药系统的构建与表征. 中国药科大学学报. 2017, 48(4):444-45.
(22) 朱红艳, 朱景平, 谢爱梅, 袁静, 花烨, 张伟*. 肿瘤靶向高分子碲化镉量子点复合纳米粒的制备及其表征. 药学学报. 2014, 49 (10): 1457 -1465.
(23) 刘婉婉，张胜喻，杨彧，朱红艳*. 具有肿瘤靶向及穿膜效应的壳聚糖胶束的制备. 中国药科大学学报. 2015, 46(5): 561-567.
(24) 周瑶，曹欣雨，周佳敏，朱红艳*. 口服维生素c脂质体的制备及其稳定性研究. 南通大学学报（医学版）. 2020, 40(5): 1-3.
(25) 发明专利：朱红艳, 许伯慧, 陈忠平. 一种仿生sirna胶束纳米复合物及应用. 专利号：zl 2015 1 0189351.6，授权日：2018.07.24.
(26) 朱红艳，赵刘碗，韩伟莉. sirna纳米载体及其制备方法和应用. 专利号：。
(27) 已经转让的专利：朱红艳, 谢爱梅, 杨池, 张贝贝, 王逸飞. 一种基于量子点的多功能纳米sirna载体系统的制备及应用. 专利号：zl 2014 1 0087972.9，转让时间：2020年，转让经费：4万元。
(28) 朱红艳,赵刘碗, 韩伟莉. 光热材料和外泌体介导的化疗药组成的药物及其用途. 申请号：2019101129258, 实审发文号：2019042800173150.